Dude this is absolutely sick. Anything I can say here is purely preference and nitpicking
The fingers on his right hand in the first panel look thicker than they should be, looks like someone took a hammer to his hand.
Not sure how it would look, but I'd love to see if adding depth to this comic blurb would make it pop more. I was thinking darkening and thickening the comic lines a bit, and adding some background shading on the second panel might be neat. (No idea though)
Lastly, your attempt with your character and despair, you've done a great job with his face already, but I feel like he's more angry than in despair. I really don't know what could fix that, so I'm hesitant to offer any sort of tips for that... Maybe add eyes? They're usually referred to as windows to the soul, so adding them in might help. Changing the eyebrow shape as well might help, they seem a little angry.
Take everything I've said with a grain of salt, I'm no artist and don't feel it's right to correct you when you're better than I am. Great job so far