My favourite, as far as aesthetics go, is, by far, DMC4's Red Queen. Such a good design.

BFG from Doom

best is the mausamune from final fantasy X

That gun is pretty hardcore..killed many bastards with that.

Whoa! thats what she said.

My fave wpn is the lawnmower from tom and jerry: housetrap. Good times. Ran over that stupid cat so many times.

My front bumper in Burnout games.
Especially Burnout Paradise.

I still say this is the best weapon.

I still win.
Destroying all cars in your way = win
flying off ramps, then landing on a car = win
spinning out of control then slamming into a railing to practically split a car in half = win
3 wins in one. :]
& I change it to my whole car in Burnout. Because i destroy with all, and I destroy all. No questions asked.

Devistator from Duke Nukem 3d

i demand this be in a video game